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2018年首都师范大学生命科学学院马力耕导师考研调剂信息

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  马力耕,男,教授,博士生导师,

  

  国家杰出青年基金获得者,北京市特聘教授,

  

  北京市高层次人才引进计划入选者。

  

  联系方式:ligengma@cnueducn

  

  教育经历

  

  1987年:河北师范大学生物学系学士学位

  

  1990年:河北师范大学生物学系硕士学位

  

  1997年:中国农业大学生物学院博士学位

  

  工作主要经历

  

  201112 首都师范大学生命科学学院教授、博士研究生导师

  

  20101 201112河北师范大学生命科学学院教授、博士研究生导师

  

  20051 20101 北京生命科学研究所研究员、博士研究生导师

  

  20008 200412美国耶鲁大学分子、细胞和发育生物学系博士后

  

  19966 20008 河北师范大学生物学系教授(1998年起博士研究生导师)

  

  19907 19966 河北师范大学生物学系助教、讲师

  

  社会兼职

  

  国际学术刊物《BMC Plant BiologyAssociate editor(副主编)(2009年起)。

  

  获奖或荣誉情况

  

  国家自然科学奖二等奖(排名第三)

  

  国家杰出青年基金获得者

  

  全国百篇优秀博士论文提名奖指导教师

  

  河北省自然科学一等奖(排名第二)

  

  教育部科技进步二等奖(排名第二)

  

  教育部霍英东教育基金会高校青年教师研究三等奖

  

  《利用DNA微阵列芯片研究拟南芥光调控发育过程》入选2002年度“中国高等学校十大科技进展”(论文第一作者,获奖排名第三)

  

  中国植物生理学会优秀论文一等奖(**)

  

  北京市中关村高端领军人才

  

  河北省省管优秀专家

  

  河北省有突出贡献的中青年专家

  

  研究生招生专业方向

  

  硕士研究生招生:植物学--植物发育分子机制

  

  博士研究生招生:细胞生物学--植物发育生物学

  

  研究方向

  

  主要研究方向是植物发育和环境适应的分子机制,研究内容为基因表达调控在植物细胞分化和适应环境的作用和机制。

  

  基因表达的调控至少发生在两个层面:转录调控和转录后调控。基因转录调控是由基因组DNA和与其紧密结合的组蛋白构成的染色质的共价修饰状态决定,即基因表达与否以及表达水平的高低在很大程度上取决于该基因染色质的表观遗传修饰状态,而染色质的修饰状态又受细胞内外信号的调控,并通过转录调控复合体对染色质的共价化学修饰实现的。基因的可变剪接是基因表达转录后水平调控的主要方式,通过基因的可变剪接,同一个基因的前体mRNA通过内含子保留、外显子跳跃以及不同3’或5’剪接位点的识别可以产生多种mRNA,也因此可以产生以下三种结果:1,增加了每个物种细胞内蛋白质的复杂性(在基因组编码基因数量一定的前提下增加了蛋白质的种类);2,降低了最常见类型mRNA(简单称为有功能mRNA)的水平进而影响该基因的功能;3,可能产生对细胞有害的蛋白质,进而妨碍该基因编码的正常形式蛋白的功能。所以,基因可变剪接的精度和效率对基因最终发挥功能有非常重要的调控作用。基因的可变剪接是由细胞内的剪接复合体(Spliceosome)实施的,剪接复合体是一个由多个蛋白构成的大的蛋白复合体,该复合体对前体mRNA剪接的精度和效率决定于组成该复合体的蛋白动态组装和解离过程,剪接复合体组分的缺失会影响它对前体mRNA剪接的精度和效率。

  

  我们实验室前期研究结果证实SKIP既是转录复合体组分, 通过调控染色质的修饰状态调控基因的转录影响植物的发育; 同时SKIP还是剪接复合体的组分,通过调控基因的可变剪接影响植物对环境的适应。我们实验室将在上述工作的基础上, 利用遗传学、生物化学、细胞生物学和分子生物学手段分析植物发育和环境适应的分子机制。

  

  发表主要论文:

  

  发表的论文被SCI收录超过50篇,被SCI引用总次数超过5000次,其中单篇论文**引用近400次(Ma et al., Plant Cell 2001),发表的主要论文有:

  

  1Wang Z Li J Chen S Heng Y Chen Z Yang J Zhou K Pei J He H* Deng XW* and Ma LG* Poaceaespecific MS1 encodes a phospholipidbinding protein for male fertility in bread wheat PNAS 2017 in press*通讯作者)

  

  2Li J Wang Z Hu Y Cao Y and Ma LG* Polycomb Group Proteins RING1A and RING1B Regulate the Vegetative Phase Transition in Arabidopsis Front Plant Sci 2017 8 867 doi 103389/fpls201700867.(*通讯作者)

  

  3Feng J., Ma LG* A Method for Characterizing Embryogenesis in Arabidopsis Journal of Visualized Experiments 2017 e55969 doi103791/55969 *通讯作者)

  

  4Shang X Cao Y and Ma LG* Alternative Splicing in Plant Genes A Means of Regulating the Environmental Fitness of Plants Int J Mol Sci 2017 18 432 doi103390/ijms18020432*通讯作者)

  

  5Feng J Li R Ma S Wu C Li Y Cao Y Ma LG* Protein Nterminal acetylation is required for embryogenesis in Arabidopsis Journal of Experimental Botany 2016, 67 4779–4789 *通讯作者)

  

  6Feng J Ma LG* NatA is required for suspensor development in Arabidopsis Plant Signaling & Behavior 2016 11e1231293*通讯作者)

  

  7 Li Y Xia C Feng J Yang D Wu F Cao Y Li L Ma LG* The SNW Domain of SKIP Is Required for Its Integration into the Spliceosome and Its Interaction with the Paf1 Complex in Arabidopsis Molecular Plant 2016 9 1040–1050 *通讯作者)

  

  8Cao Y Wen L Wang Z Ma LG* SKIP Interacts with the Paf1 Complex to Regulate Flowering via the Activation of FLC Transcription in Arabidopsis Molecular Plant 2015 8 1816–1819 *通讯作者)

  

  9 Feng J Li J Gao Z Lu Y Yu J Zheng Q Yan S Zhang W He H Ma LG* Zhu Z* SKIP Confers Osmotic Tolerance During Salt Stress by Controlling Alternative Gene Splicing in Arabidopsis Molecular Plant 2015 81038–1052 *通讯作者)

  

  10 Ning YQ Ma ZY Huang HW Mo H Zhao T Lin Li Cai T Chen S Ma LG and He XJ Two novel NAC transcription factors regulate gene expression and flowering time by associating with the histone demethylase JMJ14 Nucleic Acids Research 2015 4314691484

  

  11 Yu Y Wang J Zhang Z Quan R Zhang H Deng XW Ma LG* Huang R* Ethylene promotes hypocotyl growth and HY5 degradation by enhancing the movement of COP1 to the nucleus in the light PLoS Genetics 2013 9 e1004025doi101371/journalpgen 1004025 *通讯作者)

  

  12Wang J Yu Y Zhang Z Quan R Zhang H Ma LG Deng XW Huang R Arabidopsis CSN5B interacts with VTC1 and modulates ascorbic acid synthesis Plant Cell 2013 2562536 doi 101105/tpc112106880

  

  13Zhang Z Jones A Joo HY Zhou D Cao Y Chen S ErdjumentBromage H Renfrow M He H Temps P,.Townes TM Giles KE Ma LG and Wang H USP49 deubiquitinates histone H2B and regulates cotranscriptional premRNA splicing 2013 Genes & Development 271581–1595

  

  14Zhao H., Liu L Mo H Qian L Cao Y Cui S LiX Ma LG*The ATPbinding cassette transporter ABCB19 regulates postembryonic organ separation in Arabidopsis PLoS ONE 2013 84): e60809 doi101371/journal pone 0060809 *通讯作者)

  

  15Wang X Wu F Xie Q Wang H Wang Y Yue Y Gahura O MaS Liu L Cao Y Jiao Y Puta F McClung CR Xu X and Ma LG* SKIP is a component of the spliceosome linking alternative splicing and the circadian clock in Arabidopsis Plant Cell 2012 24 3278–3295 *通讯作者)

  

  16Yang HC Cao Y Han ZF Mo HX Fan D Li H Liu L Yue YL She C Chai JJ and Ma Ma LG* A companion celldominant and developmentallyregulated H3K4 demethylase controls flowering time in Arabidopsis via the repression of FLC expression PLoS Genetics 2012 8e1002664 *通讯作者)

  

  17FanD Dai Y Wang X Wang Z He H Yang H Cao Y Deng XW and Ma LG*. IBM1 a JmjC domaincontaining histone demethylase is involved in the regulation of RNAdirected DNA methylation through the epigenetic control of RDR2 and DCL3 expression in Arabidopsis Nucleic Acids Research 2012 4089058916 *通讯作者)

  

  18Zhao H Wang X Zhu D Cui S and Ma LG* A single amino acid substitution in a IIIF bHLH transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis Journal of Biological Chemistry 2012 2871410914121 *通讯作者)

  

  19Yang HC Mo HX Fan D Cao Y Cui SJ and Ma LG* Overexpression of a histone H3K4 demethylase JMJ15 accelerated flowering time in Arabidopsis Plant Cell Reports 2012 3112971308 *通讯作者)

  

  20Zhao H Li X and Ma LG* Basic helixloophelix transcription factors and epidermal cell fate determination in Arabidopsis Plant Signaling & Behavior 2012 715.(*通讯作者)

  

  21Wang X Ma LG* Unraveling the circadian clock in Arabidopsis Plant Signaling & Behavior 2012 82): pii e23014 *通讯作者)

  

  22Cao Y and Ma LG* Conservation and divergence of the histone H2B monoubiquitination pathway from yeast to humans and plants Frontier Biology 2011 6109117 *通讯作者)

  

  23Li W Wang Z Li J Yang H Cui S Wang X Ma LG* Overexpression of AtBMI1C a polycomb group protein gene accelerates flowering in Arabidopsis PLoS ONE 2011 6 e21364 doi101371/ journalpone 0021364*通讯作者)

  

  24Lu SX Liu H Knowles SM Li J Ma LG Tobin EM and Lin C A role for protein kinase CK2 alpha subunits in the Arabidopsis circadian clock Plant Physiology 2011 15715371545

  

  25Ma LG MicroRNAs and their targets from rice to Arabidopsis half conserved and half diverged invited comments). Frontier Biology 2010 5 34

  

  26Jiao YL Tausta SL Gandotra N Sun N Liu T Clay NK Ceserani T Chen MQ Ma LG Holford M Zhang HY Zhao HY Deng XW Nelson T A transcriptome atlas of rice cell types uncovers cellular functional and developmental hierarchies Nature Genetics 2009 41258263

  

  27Cao Y Dai Y Cui SJ Ma LG* Histone H2B monoubiquitination is required for histone H3K4 methylation of FLC/MAFs chromatin and flowering time control in Arabidopsis Plant Cell 2008202586602 *通讯作者)

  

  28Wu Y Zhu Z Ma LG Chen M The preferential retention of starch synthesis genes reveals the impact of wholegenome duplication on grass evolution Mol Biol Evol., 2008 2510031006 doi 101093/molbev/msn052

  

  29. Wang XX Ma LG* Polycombgroup PcG proteins control seed development in Arabidopsis Invited review). Journal of Integrative Plant Biology 2007 49 5259 *通讯作者)

  

  30Qin G Gu H Ma LG Peng Y Deng XW Chen Z Qu LJ Disruption of phytoene desaturase gene results in albino and dwarf phenotypes in Arabidopsis by impairing chlorophyll carotenoid and gibberellin biosynthesis Cell Research 2007 17471482

  

  31.  Jiao Y* Ma LG* Strickland E Deng XW Conservation and Divergence of LightRegulated Genome Expression Patterns during Seedling Development in Rice and Arabidopsis Plant Cell 20051732393256 *并列第一作者).

  

  32 Ma LG Chen C Liu X Jiao Y Su N Li L Wang X Cao M Sun N Zhang X Bao J Li J Pedersen S Bolund L Zhao H Yuan L Wong GKS Wang J Deng XW and Wang J An analysis of transcriptional regulation of the rice genome and its comparison to Arabidopsis Genome Research2005 1512741283

  

  33Ma LG Sun N Liu X Jiao Y Zhao H Deng XW Organspecific genome expression atlas during Arabidopsis development 2005 Plant Physiology, 1388091

  

  34Shen YP Feng SH Ma LG Lin RC Qu LJ Chen ZL Wang HY Deng XW Arabidopsis FHY1 protein stability is regulated by light via phytochrome a and 26S proteasome Plant Physiology 2005 1391234124

  

  35Feng S* Ma LG* Wang X Xie D DineshKumar S P., Wei N and Deng XW The COP9 Signalosome Physically Interacts with SCFCOI1 and Modulates Jasmonate Responses Plant Cell 2003 1510831094 *并列第一作者).

  

  36Ma LG Zhao H Deng XW Analysis of the mutational effects of the COP/DET/FUS loci on genome expression profiles reveals their overlapping yet not identical roles in regulating Arabidopsis seedling development Development 2003 130 969981

  

  37Wu P Ma LG Hou XL Wang MY Wu YR Liu FY Deng XW Phosphate starvation triggers distinct alterations of genome expression in Arabidopsis roots and leaves Plant Physiology 2003 13212601271

  

  38Ma LG Gao Y Qu LJ Chen ZL Li JM Zhao H Deng XW Genomic evidence for COP1 as a repressor of lightregulated gene expression and development in Arabidopsis Plant Cell 200214 23832398

  

  39Wang H* Ma LG* Habashi J Li JM Zhao H Deng XW Analysis of farred lightregulated genome expression profiles of phytochrome A pathway mutants in Arabidopsis Plant Journal 2002 32723734 *并列第一作者).

  

  40Holm M Ma LG Qu LJ Deng XW Two interacting bZIP proteins are direct targets of COP1mediated control of lightdependent gene expression in Arabidopsis Genes & Development 2002 16 12471259

  

  41Ma LG Li JM Qu LJ Hager J Chen ZL Zhao H Deng XW Light control of Arabidopsis development entails coordinated regulation of genome expression and cellular pathways Plant Cell 2001 13 25892607

  

  42. Wang H Ma LG Li JM Zhao H Deng XW Direction interaction of Arabidopsis cryptochromes with COP1 in light control development Science 2001 294154158

  

  43Ma LG Xu X Cui S Sun D The presence of a heterotrimeric G protein and its role in signal transduction of extracellular calmodulin in pollen germination and tube growth Plant Cell 1999 111351–1363

  

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